This study aimed to identify and critique the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing in clinical practice. Six economic evaluations of TPMT ...

This study aimed to identify and critique the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing in clinical practice. Six economic evaluations of TPMT ...

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. Major advances were made in its management based on ...

1 University of Sheffield, School of Medicine and Biomedical Sciences, Academic Unit of Molecular and Clinical Pharmacology, The Royal Hallamshire Hospital, Sheffield, UK 2 Department of ...

This manuscript provides important structural insights into the recognition and degradation of the host tRNA methyltransferase TRMT1 by SARS-CoV-2 protease nsp5 (Mpro). The data provide compelling ...