We think it most likely that he has a single large bihormonal secreting macroadenoma, which is enriched with dopamine-2 (D2) receptors. This opinion is based on the initial MRI appearance of an ...

[51] ACTH: Adrenocorticotrophic hormone ... for improvement in glucose control is desirable. Glucocorticoid receptor antagonists (mifepristone) and somatostatin receptor antagonists (pasireotide ...

The FDA has approved 43 novel drugs so far this year (January-November), compared to 52 during the same period last year. As we step ...

A number of potential targets exist for medical therapy including inhibition of steroidogenesis, inhibition of ACTH secretion and glucocorticoid receptor antagonism (Table 1). The most commonly ...

After hours: November 29 at 4:13 PM EST Loading Chart for CRNX ...

Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a clinical stage pharmaceutical company focused on the discovery, development ...

Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

In addition to curbing any body functions that are nonessential in a fight-or-flight scenario, cortisol also: The majority of ...

A young woman with a rare hormonal disorder and a rare form of cancer has revealed how both conditions have caused her skin color to change from white to black. Sabrina Gomes, 24, from Fortaleza ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Crinetics’ lead development candidate, paltusotine, is an investigational, first-in-class, oral, once-daily somatostatin receptor type ... first-in-class, oral ACTH antagonist, that is currently ...