Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...

You have full access to this article via your institution. Figure 1: Expression of cellular prion protein and its mRNA in neurons and glial cells of the ENS. It seems evident that further studies ...

Until a nucleic acid is found or a mechanism for protein-only replication demonstrated, prion is most usefully used to describe the protein-only hypothesis. The nucleic acid challenge: arguments ...