Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...

Although NMDA receptors are not GPCRs, G protein-coupled receptors can indirectly influence their expression and activity through signaling pathways, impacting various physiological processes.

Schizophrenia is thought to involve a dysfunction of glutamatergic and GABAergic signaling in the prefrontal ... Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism ...

showing that transient activation of NMDA receptors mediates this effect. To investigate the downstream signalling pathways, the authors carried out a series of experiments using selective ...

The team analyzed samples from human postmortem brains, including healthy individuals and patients at various stages of neurodegeneration. The results show a distinct distribution of NMDA ...

To capture this key step, Furukawa and his team used a technique called electron cryo-microscopy (cryo-EM), which freezes and visualizes proteins in action. First, the team had to find a way to ...