Cancer cells often become unresponsive to multiple types of therapy. It emerges that these ‘cross-resistant’ tumour cells release lipids that reprogram cells called monocytes to stop them from ...

Scientists have long known that cancer cells alter lipid metabolism, but it was generally assumed that cancer cells were gobbling up these lipids for energy—consuming the fatty molecules to help ...

This paper presents the important discovery that lipid metabolic imbalance caused by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells.

Scientists uncover how disrupted lipid metabolism fuels chronic inflammation in colorectal cancer, offering insights into new therapeutic strategies targeting pro-inflammatory and pro-resolving lipid ...

Prostate cells are stained with Oil-Red O to detect lipid droplets. Our work shows that redistribution of lipids from prostate cancer microenvironment triggers inflammation and drives prostate ...

The Farese & Walther laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and ... and how these processes function in membrane biology and cell physiology, and ...

Long focused on antioxidants, researchers are now exploring a new route to combat prostate cancer: pro-oxidants.

The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ...

The process occurs under pathophysiological conditions when cells have a much higher lipid content as seen with proliferating cancer cells, which have some of the highest lipid content conditions.

These lipids are found in the cell membranes near the SK3 channel, a protein which, as mentioned earlier, is linked to cancer cell migration. Our recent findings shed light on the distinct roles ...