Davies et al. reported that apart from the non-ATP mimetic inhibitors rapamycin and PD184352, even the most selective kinase inhibitors affected at least one additional protein kinase 27.

The N-terminal ATP-dependent ligase domain belongs to the covalent nucleotidyltransferase enzyme superfamily that includes classic RNA/DNA ligases and mRNA capping enzymes. We’ve shown that: (i) each ...

KdELECT® Kinase Assay – Broadest Dynamic Range KINOMEscan assays do not require ATP and therefore report true thermodynamic interaction affinities, as opposed to IC50 values, which can depend on the ...