Although it is known that molecules with anti-HIV activity circulate in human blood, their identification has been hampered by difficulties in the purification and characterization of such compounds.

The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...

The study introduces a first-of-its-kind blood-brain barrier-crossing conjugate (BCC) system, designed to overcome the protective barrier that typically blocks large biomolecules from reaching the ...

In healthy brains, the so-called "blood-brain barrier" shields the brain from the ... microbes can invade the brains of ...

The delivery challenge is posed by the blood–brain barrier (BBB), which prevents around 95% of small molecules, and almost all therapeutic biologics, from leaving the bloodstream and entering ...

Blood-brain barrier; BMVEC: Brain microvessel endothelial cell; HIVE: HIV-1 encephalitis; MDM: Monocyte-derived macrophage; MMA-SPM: Methylmethacrylate-sulfopropylmethacrylate; mPEG-DPSE ...

Scientists Find Way to Deliver Medicines Across Brain's Protective Barrier By Dennis Thompson HealthDay Reporter WEDNESDAY, Nov. 27, 2024 (HealthDay News) -- The blood-brain barrier is a natural ...

New York, NY [November 25, 2024]—Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach—demonstrated in mouse models and isolated human brain tissue ...

Bleeding under the skin can look like a rash. Things become most serious when the bacteria crosses the blood-brain barrier. This could mean more inflammation and swelling around the brain.

27, 2024 (HealthDay News) -- The blood-brain barrier is a natural membrane that protects your brain from toxins and germs. Unfortunately, this barrier also hampers the delivery of important ...