To investigate the pathophysiology of glycogenoses of the liver, glycerol, an endogenous precursor of glucose, was administered intravenously to eight patients and to 22 control subjects.

Furthermore, glycerol and alanine provide substrates for hepatic gluconeogenesis, which is induced by the excess of glucagon that follows insulin deficiency [16]. In the context of insulin deficiency, ...

AQP7 mRNA levels are elevated by the decrease of insulin and adrenergic receptor activation causes the AQP7 protein to translocate to the cell surface to aid efficient release of glycerol.

In addition, the corresponding decrease in the insulin signal results in upregulation of AQP7 mRNA levels. Finally, hydrolyzed glycerol is efficiently released into the bloodstream through AQP7.