The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

This inhibition of phosphodiesterase, specifically of isoenzyme III, results in an increase in cAMP in vascular tissue and platelets. The platelet aggregation cilostazol inhibits is normally ...