The acquisition cost of bivalirudin is approximately $335 per vial, with 82% and 18% of patients needing only one and two vials in REPLACE-2, respectively ( Table 1). [11,36,37] This resulted in ...

The chemistry and pharmacology, pharmacokinetics, pharmacodynamics, adverse effects, drug interactions, dosing and administration, and pharmacoeconomics of bivalirudin are reviewed; clinical ...