RESULTS: Bisphosphonates can be grouped into two pharmacologic classes with distinct molecular mechanisms of action. Nitrogen-containing bisphosphonates (the most potent class) act by inhibiting ...

Bisphosphonates are the mainstay of osteoporosis therapy. Extensive clinical evaluation supports their utility in stemming progression of the disease and in reducing fracture risk. In the course ...

Their results indicate that reveromycin A has a very different mechanism of action to bisphosphonates or calcitonin, and will not have the same limitations on its use.

Examination of the patient and review of the bone specimen. Diagnosis. Giant osteoclasts after long-term bisphosphonate use, without evidence of malignancy. Management. Interpretation of the bone ...